2026 NFL Odds Week 2: Lines, Spreads, Results For All 16 Games

Week 2 is upon us, headlined by a Thursday night clash between the Lions and Bills in Buffalo.

Here are the lines for every week two match on the bet365 Sportsbook since September 14.

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Lions @ Bills

Spread: Bills -3.5
Money Line: Bills -185, Lions +155
O/U: 53.5

Panthers @ Falcons

Spread: Falcons -1.5
Money Line: Falcons -120, Panthers +100
O/U: 44.5

Bengals @ Texans

Spread: Texas -2.5
Money Line: Texans -140, Bengals +120
O/U: 47.5

Browns @ Buccaneers

Spread: Bucs -8.5
Money line: Bucs -425, Browns +325
O/U: 40.5

Packers @ Jets

Spread: Packer -4.5
Money Line: Packers -220, Jets +180
O/U: 45.5

Vikings @ Bears

Spread: Bears -5.5
Money Line: Bears -250, Vikings +205
O/U: 48.5

Saints @ Ravens

Spread: Ravens -8.5
Money Line: Ravens -425, Saints +325
O/U: 47.5

Eagles @ Titans

Spread: Eagle -7
Money Line: Eagles -340, Titans +270
O/U: 39.5

Steelers @ Patriots

Spread: Patriots -5.5
Moneyline: Patriots -240, Steelers +195
O/U: 42.5

Jaguars @ Broncos

Spread: Broncos -2.5
Money Line: Broncos -140, Jaguars +120
O/U: 43.5

Raiders @ Chargers

Spread: Chargers -7.5
Money Line: Chargers -330, Raiders +265
O/U: 44.5

Dolphins @ 49ers

Spread: 49ers -12.5
Money line: 49ers -950, Dolphins +625
O/U: 46.5

Commanders @ Cowboys

Distribution: TBD
Money Line: TBD
O/O: TBD

Seahawks @ Cardinals

Spread: Seahawks -4.5
Money Line: Seahawks -230, Cardinals +190
O/U: 41.5

Colts @ Chiefs

Spread: Chiefs -6.5
Moneyline: Chiefs -290, Colts +235
O/U: 48.5

Giants @ Rams

Distribution: TBD
Money Line: TBD
O/O: TBD