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Oklahoma vs. Michigan Prediction, Odds, Pick For College Football Week 2


The Michigan Wolverines will host No. 11 Oklahoma Sooners on Saturday in a Week 2 Big Noon Kickoff game on FOX.

In one of the most dramatic endings in college football story, Michigan converted a miraculous Hail Mary to avoid a massive upset against Western Michigan in Week 1.

The Wolverines initially thought they had lost before the replay turned back a second on the clock, giving them one last chance at a Hail Mary. They benefited.

Despite the win, the Kyle Whittingham era got off to a rocky start as the Wolverines barely escaped a Western Michigan team that entered the game as a 27.5-point underdog. Bryce Underwood and the offense struggled mightily, managing just 13 points, 12 first downs and 276 total yards.

However, Michigan is 1-0 and now has a great opportunity to flip the script against a ranked opponent in Week 2.

Meanwhile, Oklahoma’s Week 1 opener went much better. The Sooners outscored UTEP 51-0, with John Mateer throwing for 225 yards and three touchdowns.

Oklahoma’s defense also picked up where it left off in 2025, shutting down UTEP after finishing last season as one of the top units in the country.

With that, let’s take a look at the odds for Oklahoma vs. Michigan on FanDuel Sportsbook as of Sept. 12.

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Michigan Wolverines No. 11 Oklahoma @ Odds Michigan

Money line

  • Oklahoma: -215 (bet $10 to win $10.25 total)
  • Michigan: +176 ($10 bet to win $27.60 total)

SPREAD

  • Oklahoma -5.5: -110 (bet $10 to win $19.09 total)
  • Michigan +5.5: -110 (bet $10 to win $19.09 total)

Over/Under

  • Above 43.5: -110 (bet $10 to win $19.09 total)
  • Under 43.5: -110 (bet $10 to win $19.09 total)

Oklahoma Sooners Michigan Wolverines No. 11 Oklahoma @ Michigan Prediction, Pick

From FOX Sports Research:

In Week 1, Michigan turned the ball over three times while failing to force a single punt. Underwood struggled through the air, completing just 12 of 23 passes (52.2%) for 170 yards and one interception. The Wolverines also struggled on third downs, converting just 3 of 10 attempts (30%), compared to Western Michigan’s 8-of-18 mark (44.4%).

So Oklahoma is the clear play here, right? Wrong.

This is college football, and in a big game like this, the advantage goes to the home team. Betting markets are overreacting to Michigan’s lackluster Week 1 performance. Whittingham will have his team ready to bounce back, and it’s possible the Wolverines were looking ahead to this matchup and just weren’t up for a MAC opponent.

That won’t be the case on Saturday. Michigan will be ready for a ranked opponent and a Big Noon Kickoff showdown in front of the home crowd. Back the Wolverines to come back and cover the spread.

Oklahoma Sooners Michigan Wolverines Pick: Michigan +5.5

How to watch Oklahoma vs. Michigan



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