The Arizona Cardinals will host the Seattle Seahawks on Sunday in Week 2 NFL showdown on FOX.
The defending Super Bowl champions opened their 2026 campaign with a 13-10 victory over the New England Patriots. However, quarterback Sam Darnold left in the first quarter and will miss Seattle’s Week 2 game. Drew Lock will start in his absence.
After falling behind 10-0, the Seahawks scored 13 unanswered points to start 2026 the same way they ended 2025: with a win over the Patriots. Seattle’s defense picked off Drake Maye three times and held an explosive New England offense to just 10 points.
The Seahawks allowed an NFL-high 17.2 points per game last season, and their defense already looks poised for another dominant year.
Meanwhile, the Cardinals pulled off the biggest upset of Week 1, beating the Chargers on the road as underdogs by 9.5 points. An Arizona defense that ranked near the bottom in several categories last season held Los Angeles to 14 points, 209 passing yards and 3.9 yards per carry while recording three sacks and generating consistent pressure throughout the game.
Jacoby Brissett also impressed, completing 27 of 37 passes for 277 yards and a touchdown.
Can Arizona pull off two upsets to start the season?
Let’s take a look at the odds Seahawks vs. Cardinals on FanDuel Sportsbook as of Sept. 20.
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Money line
- Seahawks: -200 (bet $10 to win $15 total)
- Cardinals: +168 ($10 bet to win $26.80 total)
SPREAD
- Seahawks -3.5: -110 (bet $10 to win $19.09 total)
- Cardinals +3.5: -110 (bet $10 to win $19.09 total)
Over/Under
- Above 41.5: -110 (bet $10 to win $19.09 total)
- Under 41.5: -110 (bet $10 to win $19.09 total)
Seahawks @ Cardinals Prediction, Pick
From FOX Sports Research:
Drew Lock impressed in relief in Week 1, completing 16 of 22 passes for 187 yards and a touchdown. However, the Patriots did not expect to face him. But the Cardinals will be. Arizona now has a full week to prepare for Lock and build its defensive game plan around stopping him.
It may be an overreaction to one game, but the Cardinals looked like a solid team capable of exceeding expectations in their first season under coach Mike LaFleur. Their defense looked completely transformed from a year ago, and Arizona now has a legitimate chance to go 2-0, especially with a backup quarterback coming to town.
The Cardinals also have no shortage of offensive weapons as Trey McBride, Jeremiah Love, Marvin Harrison Jr. and the company will try to make big numbers once again.
Get Arizona to keep this game close and cover the 3.5 point spread.
Pick: Cardinals +3.5
How to watch the Seahawks vs. Cardinals
- Date: Sunday, September 20, 2026
- Time: 4:25 pm ET
- TV: FOX
- Transmission: Watch 3 days for free on FOX One, FOXSports.comThe FOX Sports app
- Location: State Farm Stadium, Glendale, AZ
