Oklahoma State vs. Houston Prediction, Odds, Picks for College Football Week 7

No. 20 Houston faces state no. 18 Oklahoma in a top 25 matchup on Saturday in Week 7 college football on FOX.

Let’s take a look at the odds No. 18 Oklahoma State vs. No. 20 Houston at DraftKings Sportsbook on Oct. 17.

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Money line

• No. 18 Oklahoma State: +160
• No. 20 Houston: -192

SPREAD

• No. 18 Oklahoma State +4.5: -110
• No. 20 Houston -4.5: -110

Over/Under

• Above 62.5: -110
• Under 62.5: -110

From FOX Sports Research:

• Oklahoma State’s Drew Mestemaker is the Big 12’s second-leading passer (1,575) and Houston’s Conner Weigman is third with 1,428.
• Oklahoma State is the Big 12’s leading rushing offense, averaging 521.4 yards per game, while Houston is third, averaging 481.8. Both teams are top three in scoring: Houston – 40.0, Oklahoma State – 38.2.
• Since 1969-70, no team has won back-to-back years in this series. Last season, Houston went 39-17.

How to view no. 18 Oklahoma State v. No. 20 Houston

• Date: Saturday, October 17, 2026
• Time: 7:30 pm ET
• TV: FOX
• Transmission: Watch 3 days for free on FOX One, FOXSports.comThe FOX Sports app
• Location: TDECU Stadium, Houston, TX