CFB Pick ‘Em: Top Week 10 Games, Including Notre Dame-Miami, LSU-Alabama

If you plan to leave your couch on Saturday, think again. College football’s best week of the season is finally here. Week 10 features seven top-25 matchups, and the stakes couldn’t be higher.

It starts in the morning with a showdown between No. 9 BYU and No. 3 Utah, a top-10 Holy War showdown with massive Big 12 and College Football Playoff implications. Meanwhile, No. 7 Texas travels to No. 18 Missouri as the Longhorns try to avoid a daunting third loss.

In the Big Noon Kickoff, undefeated No. 8 UCLA faces a Minnesota team that was seconds away from beating No. 4 Indiana in Bloomington last week. Can the Bruins keep their perfect season alive?

In the afternoon, the rivalry is renewed as coach Lane Kiffin leads No. 14 LSU against No. 5 Alabama for the first time. And while No. 23 Oregon’s matchup with state No. Ohio’s 11 isn’t what we expected at the start of the season, it could still impact a wide-open Big Ten race.

Then comes a starry night.

Undefeated No. 1 Miami travels to South Bend to face No. 11 Notre Dame in another edition of this historic rivalry. With all the drama surrounding last year’s last playoff spot, it could be an all-time story.

That’s joined by a 2025 CFP semifinal rematch, while Georgia No. 2 travels to Oxford to face No. 10 Ole Miss with the Rebels’ season on the line. Can Ole Miss keep its playoff hopes alive, or will the Dawgs deliver a crushing blow?

Here are our expert picks for another busy Week 10 college football slate.

College football Saturday in Week 10 will require four boxes.

Breakfast starts with no. 8 UCLA at Minnesota (noon ET on FOX). Meanwhile, No. 3 Utah hosts No. 9 BYU in the Holy War and No. 18 Missouri takes on No. 7 Texas. A heated rivalry ensues in the afternoon between No. 14 LSU and No. 5 Alabama (3:30 p.m. ET), and two Big Ten powers at No. 11 Ohio State and No. 23 Oregon.

The slate is capped with CFP-defining games as No. 10 Ole Miss hosts No. 2 Georgia (7:30 p.m. ET) and No. 1 Miami traveling to South Bend to play No. 1 Notre Dame. 11.