Brock Purdy and the undefeated San Francisco 49ers (6-0) travel to Atlanta on Sunday for a rematch Michael Penix Jr. and the Falcons (2-4). The Niners have jumped out to a three-game lead in the NFC West, while the Falcons, despite their poor start, are just 1.5 games behind the Carolina Panthers in the NFC South.
San Francisco is arguably the most complete team in the NFL even though it’s the first third of the season, averaging 29.5 points per game while allowing just 18.3. Atlanta’s offense with Penix under center was dynamic in wins earlier this season against Green Bay and New Orleans, but couldn’t step up in class in the last two games against Chicago and Baltimore. The defense has been helpful but ultimately not good enough, allowing an average of 25.5 points per game.
On Monday night, the 49ers are coming off a 23-17 win over Washington at home. It was a game San Francisco dominated early, but the Commanders made it interesting late. Overall, it was another balanced performance from Kyle Shanahan the club. Prior to this win, the Niners beat Seattle 32-29 and Denver 24-14. The Falcons, meanwhile, have lost their last two – 31-23 to Chicago last week and 30-23 to Baltimore last week.
No doubt Penix’s game is a story, but almost as big is that of Sesame Robinson. The arguably NFL leading rusher carried the ball just nine times and caught just two passes last weekend. That just won’t do. Yes, the Niners’ run defense is elite, allowing 90.2 yards per game, but Robinson’s ability to take it to the house every time he touches the ball calls for him to be more involved. It is non-negotiable. Injuries for San Francisco are another story. Their defense is especially beefed up at linebacker and defensive end. Offensively, they will be without Deebo Samuel Sr.
Let’s dive into the numbers and see if we can’t find an extra sweat or two.
NBC Sports has all the latest information and analysis you need, including how to tune in for kick-off, odds from DraftKings, player news and updatesand of course our predictions and best bets for the game from our expert staff.
Game details and how to watch: 49ers vs. Falcons
- date: Sunday, October 25, 2026
- time: 1:00 p.m
- Page: Mercedes-Benz Stadium
- town: Atlanta, GA
- TV/Broadcasting: FOX
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Last Game Odds: 49ers vs. Falcons
The latest odds from Thursday courtesy of DraftKings:
- Money line: San Francisco 49ers (-155), Atlanta Falcons (+130)
- SPREAD: 49-2.5
- in total: 49.5
The money has come for the Falcons narrowing the Spread from the Niners -4.5. The total, however, is up a few points since the open to 47.5.
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Rotoworld’s best bets
Expert picks and predictions: 49 vs. Falcons
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Our model calculates predictions around every money line, spread and over/under for every game on the NFL calendar based on data points such as past performance, player matchups, betting trends and weather forecasts.
After the model finishes running, we place its projection next to the latest betting lines for the game to arrive at a relative confidence level for each bet.
Here are the best bets our model is projecting for Sunday’s game between the 49ers and Falcons:
- Money line: NBC Sports is staying away from a Moneyline game.
- SPREAD: NBC Sports is leaning a game at Falcons +2.5.
- in total: NBC Sports is recommending a Game Total UNDER 49.5 game.
Here’s why Game Total UNDER 49.5 is the best bet:
The UNDER is a matchup between the third-ranked defense in football (San Francisco, -16.9% defensive DVOA) and a Falcons offense that ranks 31st in pass attempts and 24th in passing yards. Head-to-head history has produced a combined average score of just 38.7 points over the last three meetings, with all three going UNDER. The only thing working against the UNDER is the 49’s explosive offense – they rank 3rd in points scored (29.5 per game) and 1st in offensive DVOA (37.7%). But with Deebo Samuel out and Mike Evans (Achilles) questionable, San Francisco’s receiving corps is hurting and the Falcons defense ranks 9th in yards per game allowed.
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49ers vs. Falcons: Betting Trends and Stats
- The 49ers are 4-2 against the spread this season
- The Falcons are 2-4 against the spread this season
- San Francisco is 3-3 in OVER this season
- Atlanta is 4-2 in the OVER this season
Quarterback matchup: 49ers vs. Falcons
2026 Stats: 6GP, 1460 Passing Yards, 14 TD, 2 INT, 118.1 RTG, Sacked 5 times
- falcon: Michael Penix Jr.
2026 Stats: 4GP, 944 Passing Yards, 6 TD, 1 INT, 106.0 RTG, Sacked 9 Times
49ers vs. Falcons: Best Playmakers
49 years old
2026 Stats: 6GP, 77 carries for 350 Yds, 7 TD / 28 receptions on 35 targets for 190 Yds, 0 TD
2026 Stats: 6GP, 26 catches on 36 targets for 337 yds, 5 TD
2026 Stats: 6GP, 27 Catches on 39 Targets for 420 Yds, 3 TD
falcon
2026 Stats: 6GP, 111 carries for 641 Yds, 4 TD / 20 receptions on 28 targets for 144 Yds, 1 TD
2026 Stats: 6GP, 53 carries for 211 Yds, 4 TDs / 5 receptions on 6 targets for 30 Yds, 0 TDs
2026 Stats: 6GP, 31 catches on 47 targets for 550 Yds, 0 TD / 2 carries for 4 Yds, 0 TD
49ers vs. Falcons: Injury update
49 years old
- WR Mike Evans (Achilles) is listed as questionable for Sunday’s game
- WR Deebo Samuel Sr. (hamstring) has been ruled OUT for Sunday’s game
- OF Nick Bosa (calf) is listed as questionable for Sunday’s game
- OF Michael Williams (knee) is listed as questionable for Sunday’s game
- LB Jaden Dugger (knee) is listed as questionable for Sunday’s game
- LB Luke Gifford (groin) is listed as questionable for Sunday’s game
- SS Acronym brands (ankle) is listed as questionable for Sunday’s game
- SS Ashtyn Davis (undisclosed) is listed as questionable for Sunday’s game
- LB Garrett Wallow (undisclosed) has been ruled OUT for Sunday’s game
- FS Siran Neal (undisclosed) is listed as questionable for Sunday’s game
- CB Upton Stout (shoulder) is listed as questionable for Sunday’s game
falcon
- WR Caleb Douglas (ankle) is listed as questionable for Sunday’s game
- OT Michael Jerrell (undisclosed) is listed as questionable for Sunday’s game
- WR Olamide Zaccheaus (shoulder) is listed as questionable for Sunday’s game
- LB Divine Deablo (arm) is listed as doubtful for Sunday’s game
- OF Samson Ebukam (undisclosed) is listed as questionable for Sunday’s game
- CB CJ Henderson (groin) is listed as questionable for Sunday’s game
- CB Avieon Terrell (undisclosed) is listed as questionable for Sunday’s game
- OF Za’Darius Smith (undisclosed) is listed as questionable for Sunday’s game
- DT Anthony Thompson (undisclosed) has been ruled OUT for Sunday’s game
- CB Billy Bowman Jr. (hamstring) is listed as questionable for Sunday’s game
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