Iowa vs. Northwestern Prediction, Odds, Picks For College Football Week 10

The Northwestern Wildcats take on the No. 1 Iowa Hawkeyes. 19 on Saturday in the 10th week college football match on FOX.

Let’s take a look at the odds Iowa vs. Northwestern at DraftKings Sportsbook as of Nov. 7.

This site may contain affiliate links to legal sports betting partners. If you register or place a bet, FOX Sports may be compensated. Read more about Sports betting on FOX Sports.

Money line

• Northwest: +114
• Iowa: -135

SPREAD

• Northwest +2.5: -115
• Iowa -2.5: -105

Over/Under

• Over 43.5: -110
• Under 43.5: -110

From FOX Sports Research:

• Iowa has won six of its last 10, winning the last four against Northwestern.
• Northwestern averages the second most points per game in the Big Ten (33.6), behind only Ohio State. Meanwhile, Iowa allows the second fewest in the conference (12.5).
• Northwestern will be without quarterback Aidan Chiles, the Big Ten’s fourth-leading passer with 1,898 yards.

How to view no. 19 Iowa vs. Northwestern

• Date: Saturday, November 7, 2026
• Time: 7:30 pm ET
• TV: FOX
• Transmission: Watch 3 days for free on FOX One, FOXSports.comThe FOX Sports app
• Location: Ryan Field, Evanston, IL