The Indianapolis Colts visit the Kansas City Chiefs on Sunday, September 20, 2026 at 8:20 PM ET from Arrowhead Stadium in Kansas City, Missouri. Kansas City is 1-0 after a 31-10 win over Denver, while Indianapolis is 0-1 after a 41-23 loss to Baltimore.
Kansas City’s opening drive went to the ground game. Kenneth Walker carried 23 times for 173 yards and a touchdown, added three catches for 18 yards and another score, and the Chiefs finished with 220 rushing yards in the win over the Broncos.
Indianapolis couldn’t keep pace with the Ravens. Daniel Jones threw for 166 yards and a touchdown, but the Colts managed 251 total yards and converted just 30 percent of their third downs.
The Chiefs are 6.5-point favorites over the Colts, with a total of 46.5 and a money line of -305 for the Chiefs and +245 for the Colts.
Below, we’ll give you all the details you need to know about how to watch this game.
How to watch Colts vs. Chiefs
- When: Sunday, September 20, 2026 at 8:20 PM ET
- Where: Arrowhead Stadium, Kansas City, MO
- TV: NBC
- Transmission: peacock
Players to watch
Kansas City’s ground game is the first thing to watch here, and Walker sits at the center of it. In Week 1, he powered the Chiefs with 23 carries for 173 yards and 1 rushing touchdown, then added 3 catches for 18 yards and a receiving score, matching a team that had 220 rushing yards and 5.79 yards per attempt.
Indianapolis gave up 41 points in its opener and ranks 31st in points allowed per game. Walker going down early on downs could force the Colts to crowd the box and open up the rest of the offense, allowing Kansas City to dictate the tempo from the first quarter onward.
This game could hinge on whether Indianapolis slows down Kansas City behind the sellout against the run, which puts Mahomes under the microscope next. He led the Chiefs in Week 1 with 184 passing yards and 2 touchdown passes as Kansas City still scored 31 points despite a modest 55.6 completion rate.
The Colts allowed 41 points in Week 1, while Kansas City is coming off a 31-10 victory with a balanced offense that shot 52.9 percent on third downs. Mahomes hooking up with Travis Kelce (71 yards on 3 catches, including a 59-yard gain) is the most obvious way to punish a defense that relies heavily on Walker.
Indianapolis needs more of its passing game in this matchup, which makes Jones one of the biggest swing players on the field. In Week 1 he led the Colts with 166 passing yards and 1 touchdown, but the offense averaged just 149 passing yards and 251 total yards while converting just 30 percent of third downs.
Kansas City allowed just 10 points in Week 1, ranks second in points allowed per game and posted 4 sacks with 1 interception. Jones getting the ball out on time and avoiding the mistakes that put Indianapolis behind the schedule gives the Colts a chance to keep this from being a one-sided night.
Indianapolis needs an explosive element in the passing game, and Pierce has already shown signs of being that player. He led the Colts with 61 receiving yards in Week 1 and was a full participant in Wednesday’s practice, looking determined for this game in an offense that managed just 166 receiving yards and a longer completion of 25 yards in the opener.
Kansas City’s defense opened with 4 sacks, 1 interception and only 10 points allowed, so it could be tough to get to. Pierce creating plays gives Jones a way to challenge a defense that has looked tight and aggressive.
Colts vs. Chiefs odds
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