Raiders quarterback Fernando Mendoza will make his first career start on Sunday. Two others will also make their debuts: Cardinals quarterback Carson Beck and Dolphins quarterback Kyle McCord.
They would become the 48th, 49th and 50th different quarterbacks to start games during the 2026 season, according to NBC Sports research.
It will be just the second time in the last 15 years (excluding the 1987 blowout season) that 50 different quarterbacks have started games in the first 10 weeks of a season.
If, for some reason, another quarterback makes his first start of the season on Sunday (which is unlikely unless Seahawks quarterback Drew Lock has an injury determination for Sunday), he will be the second-most starters in 10 weeks since 1950.
In 1999, 55 different quarterbacks started games through the first 10 weeks of the season.
Most of the changes have come from injury. For the Raiders, the move to Mendoza happened after Kirk Cousins was traded to the Vikings.