Cowboys vs. 49ers Prediction, Odds, Pick For NFL Week 10

The San Francisco 49ers will visit the Dallas Cowboys on Sunday in Week 10 NFL showdown on FOX.

Let’s take a look at the odds Cowboys vs. 49ers on FanDuel Sportsbook as of Nov. 15.

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Money line

SPREAD

• 49-4.5: -108
• Cowboys +4.5: -112

Over/Under

• Over 55.5: -102
• Under 55.5: -118

From FOX Sports Research:

• Both teams are ranked in the top six in terms of scoring. San Francisco is third with 29.4 points per game and Dallas is sixth with 27.3. They combined for 54 points in their last meeting, a 30-24 49ers victory.
• The 49ers lead the NFL with 6.3 yards per play and rank second in third down conversion rate (51.7%). The Cowboys rank fifth in third down (45.3%) and third in red zone drop rate (71.4%).
• Brock Purdy and Dak Prescott have thrown at least one pass in every game this season. Purdy has five passing yards and zero interceptions in three meetings with Prescott, who tied his season best with 335 passing yards last week.
• Christian McCaffrey and Javonte Williams each have 10 tackles, a mark only five players have accomplished this season. CeeDee Lamb ranks second in the NFL with 904 receiving yards, and George Kittle ranks third among tight ends with 483.

How to watch Cowboys vs 49ers

• Date: Sunday, November 15, 2026
• Time: 4:25 pm ET
• TV: FOX
• Transmission: Watch 3 days for free on FOX One, FOXSports.comThe FOX Sports app
• Location: AT&T Stadium, Arlington, TX