Will history repeat itself in Saturday’s Ohio State-Texas battle or will the Longhorns find a way to win?
And which team will start the weekend with a clean record after the Missouri-Kansas tilt?
Here are five college football games to watch for week two.
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Friday, September 11
Spread: Missouri -5.5
Money line: Missouri -218; Kansas +180
O/U: 51.5
What you need to know: Missouri cruised to an easy straight-up (SU) win over Arkansas-Pine Bluff in Week 1. However, the Tigers were unable to cover the 54.5-point spread as the final score was Mizzou 54, Pine Bluff 14. This week, Missouri faces a tougher opponent in Kansas. Unlike the Tigers, the Jayhawks covered the 41-point spread in their game by defeating Long Island University 51-6. When these two teams met last season in Missouri, the Tigers won 42-31. “The Tigers have the best quarterback, and their running game is still pretty great without Ahmad Hardy in the backfield,” explained FOX Sports college football writer RJ Young of his pick of Mizzou over Kansas.
Saturday, September 12
Spread: Oregon -23.5
Money line: Oregon -2100; OSU +1100
O/U: 57.5
What you need to know: Oregon got a scare last week when Boise State kept it close even in the fourth quarter. The Ducks ended up winning 34-27, but did not cover the 24.5 point spread. On the other hand, Oklahoma State lost to Tulsa in Week 1 24-10. While the Cowboys controlled the ball for more minutes, they had four turnovers and six penalties for 59 yards. In 2025, Oregon won easily when they faced each other, defeating Oklahoma State 69-3. “The Ducks had their ‘wake-up call’ last week against Boise State,” noted FOX Sports football and college football writer Laken Litman, “but Dan Lanning will have his team ready to go.”
Dante Moore and the Ducks struggled in Week 1. Was it a wake-up call? (Getty Images)
Spread: Oklahoma -5.5
Money line: Oklahoma -218; Michigan +180
O/U: 43.5
What you need to know: It took an arm and a prayer, two Hail Marys and one controversial extra second on the clock for Michigan to beat Western Michigan in Week 1. But the football gods fell on the Wolverines’ side and they narrowly escaped 13-12. The loss dropped them from No. 16 overall to outside the Top 25. Will Michigan bounce back in Week 2? FOX sports betting analyst Will Hill believes UM will at least cover. “The Wolverines still seem to have a very solid defense. he wrote. “They need to be able to adopt an ‘Us against the World’ mentality – especially as a ‘dog’ at home.”
Spread: Tennessee -12.5
Money line: Tennessee -470; Georgia Tech +360
O/U: 55.5
What you need to know: Georgia Tech’s 2026 got off to a rocky start as the Yellow Jackets were upset by Colorado in Atlanta. Tech now hosts double-digit favorite Tennessee. It’s been nine years since these two played each other and it ended in a double overtime victory for Rocky Top. In Tech’s loss last week, the Jackets racked up 288 yards of total offense. The Vols rolled 638 against Furman in their Week 1 win.
Spread: Texas -1.5
Money line: Texas -122; Ohio State +102
O/U: 49.5
What you need to know: Both of these teams are near the top of the national championship and both have players near the top of the Heisman table as well. So which title contender comes out of week two unscathed? RJ Young picked Ohio State, noting that wide receiver Jeremiah Smith is a “cheat code.” For added context, in last year’s battle, the Buckeyes took the win 14-7 on their home turf.